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British Ivermectin Recommendation Development Group. The BIRD Recommendation on the Use of Ivermectin for COVID-19. 2021. https://bird-group.org/wp-content/uploads/2021/03/BIRD-proceedings-02-03-2021_v1.5.1.pdf (accessed 11 July 2021)

Bryant A, Lawrie TA, Dowswell T Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines. Am J Ther.. 2021; 28:(4)e434-e460 https://doi.org/10.1097/MJT.0000000000001402

Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM. The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Res.. 2020; 178 https://doi.org/10.1016/j.antiviral.2020.104787

Dinis-Oliveira RJ. COVID-19 research: pandemic versus “paperdemic”, integrity, values and risks of the “speed science”. Forensic Sci Res.. 2020; 5:(2)174-187 https://doi.org/10.1080/20961790.2020.1767754

Doshi P. Covid-19 vaccines: In the rush for regulatory approval, do we need more data?. BMJ.. 2021; 373 https://doi.org/10.1136/bmj.n1244

Statement of Concern and Request for Retraction. 2021. https://trialsitenews.com/wp-content/uploads/2021/07/LetterToEditorReRoman-et-al-3-July-2021_R.pdf (accessed 11 July 2021)

Johnson RM, Doshi P, Healy D. Covid-19: Should doctors recommend treatments and vaccines when full data are not publicly available? BMJ. 2020; 370 https://doi.org/10.1136/bmj.m3260

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Understanding ivermectin

02 August 2021
Volume 3 · Issue 8

Abstract

George Winter examines the ongoing discussion as to whether ivermectin can be used in the treatment of COVID-19, breaking down opposing viewpoints, the integrity of research, and the need for further analysis

When the implications of the unfolding COVID-19 pandemic dawned, the race for effective vaccines and/or treatments began. However, as Dinis-Oliveira (2020) notes, the scientific approach ranged ‘from robust studies to dishonest studies being conducted, posted, and shared at an unprecedented rate’, and he asks for balance ‘between the benefits of the rapid access to new scientific data and the threat of causing panic or erroneous clinical decisions based on mistakes or misconduct.’

When Johnson et al (2020) debated the question of whether doctors should recommend treatments and vaccines against COVID-19 and its causative agent SARS-CoV-2, one contributor argued that ‘unpublished trial results, even with limited data transparency and peer review, can deliver crucial interventions without sacrificing integrity’, whereas others contended that ‘doctors and professional societies should publicly state that, without complete data transparency, they will refuse to endorse COVID-19 products as being based on science’ (Johnson et al, 2020). Further, while Doshi (2021) acknowledged that global vaccination against COVID-19 was underway, he cautioned that although it might be seen as nit-picking, the fact remained that ‘none of the COVID-19 vaccines in use are [sic] actually “approved.” Through an emergency access mechanism known as Emergency Use Authorisation (EUA), the products being rolled out still technically remain “investigational”’ (Doshi, 2021).

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