In the UK, the Medicines and Healthcare products Regulatory Agency (MHRA) grants licences that confirm the specific medical condition a drug should be used for, alongside the recommended dosage. This...
A neonate, weighing 700 g is prescribed a dopamine infusion. What is the initial dose? What is the maximum dose and infusion rate?
The neonatal period refers to the first 28 days of life for a term infant. Prescribing for neonates differs from that for older children and adults due to differences in anatomy and physiology,...
The third aspect of pharmacokinetics (after absorption and distribution) is metabolism. Most drugs are metabolised in the liver, but can also occur in the gastrointestinal tract, the blood, the...
There are many legal aspects to consider when entering into independent prescribing, alongside regulatory frameworks and ethical principles. Prescribing professionally requires an awareness of...
Since the discovery of the smallpox vaccine in the late 18th century, it is still estimated that 20% of deaths in children under 5 years of age are due to diseases that can be prevented by current...
There is a continuing need for pharmaceutical companies to manufacture age-appropriate medications for children. It is not just preferences for particular formulations that need to be considered, but...
Excretion is the final phase of the drug's journey as it passes through the body, and this elimination – usually by the kidneys – depends on glomerular filtration, tubular excretion and also tubular...
Distribution is the second part of the pharmacokinetic process after Absorption, and it is here where drugs pass from the bloodstream to the body’s organs and tissues. When prescribing for children,...
This cohort study, published in The Lancet Psychiatry journal, aimed to identify trends in antipsychotic drug prescribing to children and adolescents in England (Radojčić et al, 2023). This was driven...
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