References

Corbyn Z This scientist treated her own cancer with viruses she grew in the lab. Nature. 2024; 635:(8039)529-530 https://doi.org/10.1038/d41586-024-03647-0

Goodwin CS Helicobacter pylori: 10th anniversary of its culture in April 1982. Gut. 1993; 34:(3)293-4 https://doi.org/10.1136/gut.34.3.293

Marshall BJ History of the Discovery of C. pylori. In: Blaser MJ (ed). New York: Igaku-Shoin; 1989

NHS. Treatment; alcohol misuse. 2024. https://www.nhs.uk/conditions/alcohol-misuse/treatment/ (accessed 17 November 2024)

Norwitz NG, Cromwell WC Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment. Metabolites. 2024; 14:(1) https://doi.org/10.3390/metabo14010073

Pal A, Pattanayak RD, Sagar R Tracing the Journey of Disulfiram: From an Unintended Discovery to a Treatment Option for Alcoholism. J Mental Health Hum Behav. 2015; 20:41-43 https://doi.org/10.4103/0971-8990.164826

Weisse AB Self-Experimentation and Its Role in Medical Research. Tex Heart Inst J. 2012; 39:(1)51-54

Self-experimentation

02 December 2024
Volume 6 · Issue 12

Abstract

In this month's article, George Winter discusses examples throughout history of medical self-experimentation by researchers

The scientific literature has abundant accounts of human volunteers participating in medical experiments, but self-experimentation in a medical context is less well documented. By 2012, there were ‘465 documented instances of this practice, performed over the course of the past two centuries’ (Weisse, 2012), and self-experimentation had reached its peak in the first half of the 20th century, with eight deaths occurring.

For example, Pal et al (2015) describe the role of self-experimentation in helping to establish disulfiram – tetraethylthiuram disulfide (Antabuse®) – as a deterrent for patients with alcohol use disorders. First synthesised in 1881 by German chemist M. Grodzki, disulfiram was found to be useful in the vulcanisation of rubber, but ‘the distress among the workers involved in the processing of the substances after ingesting alcohol’ was recorded (Pal et al, 2015).

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