Drug breakdown: Nystatin

Day 1: Discovered via painstaking screening of soil samples in 1950 by Elizabeth Lee Hazen and Rachel Fuller Brown, #nystatin is a mixture of antifungal polyenes derived from the bacteria Streptomyces noursei. From the hundreds of cultures tested, the species was discovered in the garden of a friend, surname Nourse! #nystatin is so-called because the women worked at the New York State Dept of Health.

Day 2: #nystatin is a broad spectrum anti-fungal used for oral cavity candida infections. Oral suspension 1 ml (100 000 units) is dropped into the mouth after food four times daily for 7 days; Half the dose to each side of the mouth. Usually, second line to miconazole/used when miconazole is not suitable. #nystatin can be used to soak dentures overnight to prevent recurrence of oro-pharangeal thrush, in conjunction with miconazole/fluconazole treatment.

Day 3: #nystatin suspension is rinsed around and held in the mouth for as long as possible before spitting out. It should be continued for 48 hrs after lesions resolve. #nystatin is also added to some steroid, antiseptic and antibiotic creams for a Candida component of skin infections. Used in all age groups, but unlicensed in UK for neonates.