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Drug Breakdown

INCLISIRAN

Day 1: Approved in Europe in 2020, the novel lipid lowering drug #inclisiran acts on PCSK9, a known lipid pathway target; this gene therapy ‘switches off’ the enzyme (mimicking the natural mechanism...

LEVODOPA

Day 1: Still the mainstay of Parkinson's disease (PD) treatment, #levodopa was extracted from faba bean seedlings in the early 20C. It was deployed in the 1960s with dramatic ‘wakening’ effects on...

Metronidazole

Day 1: Known as an antibiotic with anti-parasitic properties, #metronidazole was discovered in the 1960s for efficacy against amoebic dysentery. This led to the accidental discovery of activity...

TIRZEPATIDE

Day 1: Following the diabetes & weight loss successes of GLP-1 agonists such as semaglutide, #tirzepatide is the 1st ‘dual’ incretin drug. Peptide engineering has been used to bring GLP-1 activity...

Oxybutynin

Day 1: #oxybutynin is an anti-muscarinic drug approved in 1970s for incontinence & overactive bladder. #oxybutynin remains a 1st-line drug in UK. Side effects, especially dry mouth can lead to...

VORTIOXETINE

Day 1: #vortioxetine is a unique antidepressant, discovered from exploring bis-aryl-sulfanyl amine compounds. It is categorised as a ‘serotonergic’ drug, acting both as an SSRI & as a serotonin...

Daptomycin

Day 1: #daptomycin was discovered in the late 1980s, when Streptomyces roseoporus bacteria was isolated from a Turkish soil sample. Adverse effects led to delays in clinical trials...

Drug breakdown: Penthrox

With the help of Prescribing and Therapeutics Training Ltd and the Journal of Prescribing Practice, you can earn your 1-hour CPD certificate

Zopiclone

With the help of Prescribing and Therapeutics Training Ltd and the Journal of Prescribing Practice, you can earn your 1-hour CPD certificate.

Tacrolimus

Day 1: In the same class as ciclosporin A (superior to), #tacrolimus was found in Japan ©1984 from soil bacterium strep. tsukubaensis; the name is a combination of tsuku, macrolide and...

Drug breakdown: Indapamide

With the help of Prescribing and Therapeutics Training Ltd and the Journal of Prescribing Practice, you can earn your 1-hour CPD certificate.

Drug breakdown: caffeine

Day 1: Used for centuries as a stimulant, #caffeine was found via coffee bean analysis circa 1820, but is also found in the cocoa bean, guarana seeds, tea leaves etc; #caffeine can also be synthesised...

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