Day 1: As it is chemically related to the neurotransmitter GABA, #baclofen was trialed for epilepsy in the 1960s, but found ineffective, However, a centrally acting muscle relaxant effect was...
Day 1: #melatonin is derived from the pineal gland & was first isolated in the late 1950s. Named from observation of altered frog pigmentation, but the role for human melanin is unknown. Known for...
Day 1: Convinced that rheumatoid arthritis (RA) had a bacterial cause, Professor Nanna Svartz tested sulfapyridine on her patients. After minimal success, a drug company helped her to combine this...
Day 1: Approved in Europe in 2020, the novel lipid lowering drug #inclisiran acts on PCSK9, a known lipid pathway target; this gene therapy ‘switches off’ the enzyme (mimicking the natural mechanism...
Day 1: Still the mainstay of Parkinson's disease (PD) treatment, #levodopa was extracted from faba bean seedlings in the early 20C. It was deployed in the 1960s with dramatic ‘wakening’ effects on...
Day 1: Known as an antibiotic with anti-parasitic properties, #metronidazole was discovered in the 1960s for efficacy against amoebic dysentery. This led to the accidental discovery of activity...
Day 1: Following the diabetes & weight loss successes of GLP-1 agonists such as semaglutide, #tirzepatide is the 1st ‘dual’ incretin drug. Peptide engineering has been used to bring GLP-1 activity...
Day 1: #oxybutynin is an anti-muscarinic drug approved in 1970s for incontinence & overactive bladder. #oxybutynin remains a 1st-line drug in UK. Side effects, especially dry mouth can lead to...
Day 1: #vortioxetine is a unique antidepressant, discovered from exploring bis-aryl-sulfanyl amine compounds. It is categorised as a ‘serotonergic’ drug, acting both as an SSRI & as a serotonin...
Day 1: #daptomycin was discovered in the late 1980s, when Streptomyces roseoporus bacteria was isolated from a Turkish soil sample. Adverse effects led to delays in clinical trials...
With the help of Prescribing and Therapeutics Training Ltd and the Journal of Prescribing Practice, you can earn your 1-hour CPD certificate
With the help of Prescribing and Therapeutics Training Ltd and the Journal of Prescribing Practice, you can earn your 1-hour CPD certificate.
Journal of Prescribing Practice shares the latest clinical expertise and professional guidance for non-medical prescribers. Our goal is to provide the knowledge to help you prescribe more efficiently and effectively.
Evidence-based best practice
Drug updates
Pharmacology information
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