Drug Breakdown: MEBENDAZOLE
Abstract
In this column, Sharon Rees aims to refresh knowledge and interest in some of the commonly used drugs in a series of posts on X. This month she is talking about #mebendazole
Day 1: #mebendazole is a synthetic benzimidazole derivative, designed as a broad spectrum anthelmintic drug for intestinal nematodes. Licensed in 1970s. This drug class is selectively toxic to nematode (worm) tubulin & has a high cure rate in threadworm infections
Day 2: #mebendazole comes as suspension or chewable tablets licensed for thread/whip/hook/roundworm infections for children aged over 2 & adults. Standard dose adult/child for threadworm 100mg then 2nd dose after 2 weeks (available OTC). Whip/hook/roundworm 100mg bd for 3 days. For threadworm infection, high transmissibility means it is necessary to treat all family members at same time. #mebendazole can be used from 6 months+ (unlicensed), but as convulsions have been reported ‘rarely’; risk/benefit must be carefully considered
Day 3: #mebendazole has poor absorption from GI tract, so is ideal for gut infections while conferring low systemic toxicity. When used for chronic infections, greater systemic absorption occurs. Undergoes hepatic metabolism & some enterohepatic recycling; excreted mostly in faeces t½ 3-6 hrs
Register now to continue reading
Thank you for visiting Journal of Prescribing Practice and reading some of our peer-reviewed resources for prescribing professionals. To read more, please register today. You’ll enjoy the following great benefits:
What's included
-
Limited access to our clinical or professional articles
-
New content and clinical newsletter updates each month