Ganciclovir dosing in children: answers
Abstract
QUESTION 1
Calculate the body surface area (BSA) for this child, given that their length is 47 cm, using the Mostellar formula (Akkawi El Edelbi et al, 2023): BSA (m^2) = √((height (cm) × weight (kg)) / 3600)
- Height = length = 47 cm, weight = 2.2 kg
- 47 cm × 2.2 kg = 103.4 cm.kg
- 103.4 / 3600 = 0.029
- √0.029 = 0.17 m^2
QUESTION 2
We will need to calculate renal function using the Schwartz equation, but this uses creatinine in mg/dl, and the lab reports creatinine in micromolar. Micromolar / 88.4 will convert micromolar to mg/dl (GlobalRPh, 2019). If the lab creatinine level for this patient is 52 micromolar, what is the value of creatinine to use in the Schwartz equation?
- 52 micromolar / 88.4 = 0.59 mg/dl
Calculate the body surface area (BSA) for this child, given that their length is 47 cm, using the Mostellar formula (Akkawi El Edelbi et al, 2023): BSA (m^2) = √((height (cm) × weight (kg)) / 3600)
We will need to calculate renal function using the Schwartz equation, but this uses creatinine in mg/dl, and the lab reports creatinine in micromolar. Micromolar / 88.4 will convert micromolar to mg/dl (GlobalRPh, 2019). If the lab creatinine level for this patient is 52 micromolar, what is the value of creatinine to use in the Schwartz equation?
Calculate an eGFR for this patient using the Schwartz equation: eGFR (ml/min/1.73 m^2) = (0.33 × height (cm)) / creatinine level (mg/dl).
Based on your answers to Questions 1 and 3 above, what dose will be needed for this patient?
If the solution was diluted to the maximum possible concentration, what infusion rate will be needed in ml/hour?
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