Excipient induced laxative thresholds: answers

02 November 2023
Volume 5 · Issue 11

Based on the information above, what is the minimum expected amount of sorbitol (in g) for an adult that could produce a laxative effect?

Assuming the dose from Q1 is effective for a 70 kg adult, calculate a dose, in g/kg, that could be extrapolated for use in patients of different sizes.

What is the daily dose of each polyol that a 2-year-old boy would receive if treated with Clarityn syrup?

If the 2 year old weighs 12 kg what is the dose per kg of each polyol?

What proportion of the usually pharmacologically effective dose of each polyol will this child receive?

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