Excipient induced laxative thresholds: answers
Based on the information above, what is the minimum expected amount of sorbitol (in g) for an adult that could produce a laxative effect?
Assuming the dose from Q1 is effective for a 70 kg adult, calculate a dose, in g/kg, that could be extrapolated for use in patients of different sizes.
What is the daily dose of each polyol that a 2-year-old boy would receive if treated with Clarityn syrup?
If the 2 year old weighs 12 kg what is the dose per kg of each polyol?
What proportion of the usually pharmacologically effective dose of each polyol will this child receive?
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