Dosing of mesna to avoid urothelial toxicity from cyclophosphamide infusion: answers
Given that they weigh 7 stone 13lb and are 5′4′′ tall, use the Mosteller (1987) formula (Figure 1) for body surface area to calculate the dose determining body surface area in m2.
Putting these into Mosteller:
Using your answer to question 1, calculate the cyclophosphamide dose required. The clinicians would like to use the lower end of the summary of product characteristics (2014) recommended dose of cyclophosphamide for autoimmune disorders; 500 mg/m2 every fortnight initially.
How much mesna is required for each dose for this patient?
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