Classification of antibiotics – the glycopeptides: answers

An adult, weight 75 kg, is diagnosed with severe community-acquired pneumonia and prescribed vancomycin. A loading dose of 26 mg/kg (max 2 g) by intravenous infusion is given and a maintenance dose of 20 mg/kg is prescribed. A high vancomycin plasma concentration is obtained, and the maintenance dose is decreased by 10%.

A neonate aged 32 weeks, weight 1560 g, is diagnosed with bacterial meningitis and prescribed vancomycin. They are prescribed 15 mg/kg every 12 hours to be adjusted in response to serum plasma concentration. What is the initial prescribed dose?

An adult, weight 43 kg, is diagnosed with streptococcal endocarditis and prescribed teicoplanin. They are prescribed 12 mg/kg by intravenous infusion.

What is the initial prescribed dose?

A 1-month-old child, weight 7 kg, is diagnosed with cellulitis and prescribed teicoplanin. Initial loading dose is 16 mg/kg followed by 8 mg/kg maintenance dose.