References

Abdel-Tawab R, Higman James D, Fichtinger A, Clatworthy J, Horne R, Davies G. Development and validation of the Medication-Related Consultation Framework (MRCF). Patient Educ Couns. 2011; 83:(3)451-457 https://doi.org/10.1016/j.pec.2011.05.005

Beuscart J, Petit S, Gautier S Polypharmacy in older patients: identifying the need for support by a community pharmacist. BMC Geriatrics. 2019; 19 https://doi.org/10.1186/s12877-019-1276-y

Chaplin S. Do multidose compliance aids do more harm than good?. Prescriber. 2017; 28:(6)30-32 https://doi.org/https://onlinelibrary.wiley.com/doi/pdf/10.1002/psb.1582

Cutler RL, Llimos F, Frommer M Economic impact of medication non-adherence by disease groups: a systematic review. BMJ Open. 2018; 8 https://doi.org/10.1136/bmjopen-2017-016982

DiMatteo MR. Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. Med Care. 2004; 42:(3)200-209 https://doi.org/10.1097/01.mlr.0000114908.90348.f9

European Patients' Forum. Adherence and concordance. 2015. https://tinyurl.com/yyzmodr7 (accessed 10 September 2020)

Henry SG, Fuhrel-Forbis A, Rogers MAM, Eggly S. Association between nonverbal communication during clinical interactions and outcomes: a systematic review and meta-analysis. Patient Educ Couns. 2012; 86:297-315 https://doi.org/10.1016/j.pec.2011.07.006

Holmes EAF, Hughes DA, Morrison VL. Predicting adherence to medications using health psychology theories: a systematic review of 20 years of empirical research. Value Health. 2014; 17:(8)863-876 https://doi.org/10.1016/j.jval.2014.08.2671

Concordance, adherence and compliance in medicine taking. 2005. https://tinyurl.com/pvdbh4p (accessed 10 September 2020)

Horne R, Chapman SCE, Parham R, Freemantle N, Forbes A, Cooper V. Understanding patients' adherence-related beliefs about medicines prescribed for long-term conditions: a meta-analytic review of the Necessity-Concerns Framework. PLoS One. 2013; 8:(12) https://doi.org/10.1371/journal.pone.0080633

Jensen GA, Li Y. Long˝run health effects of cost˝related non˝ adherence to prescribed medications among adults in late midlife. J Pharm Health Serv Res. 2012; 3:(2)85-93 https://doi.org/10.1111/j.1759-8893.2012.00087.x

Linn AJ, Weert JCM van, Dijk L van, Horne R, Smit EG. The value of nurses' tailored communication when discussing medicines: exploring the relationship between satisfaction, beliefs and adherence. J Health Psychol. 2016; 21:(5)798-807 https://doi.org/10.1177/1359105314539529

Maffoni M, Traversoni S, Costa E, Midão L, Karda P, Kurczewska-Michalak M, Giardini A. Medication adherence in the older adults with chronic multimorbidity: a systematic review of qualitative studies on patient's experience. Eur Geriatr Med. 2020; 11:369-381 https://doi.org/10.1007/s41999-020-00313-2

Morgan SG, Lee A. Cost-related non-adherence to prescribed medicines among older adults: a cross-sectional analysis of a survey in 11 developed countries. BMJ Open. 2017; 7:(1) https://doi.org/10.1136/bmjopen-2016-014287

Mortazavi SS, Shati M, Keshtkar A Defining polypharmacy in the elderly: a systematic review protocol. BMJ Open. 2016; 6 https://doi.org/10.1136/bmjopen-2015-010989

National Institute for Health and Care Excellence. Medicines adherence: involving patients in decisions about prescribed medicines and supporting adherence. CG76. 2009. https://tinyurl.com/qa2ozb3 (accessed 10 September 2020)

National Institute for Health and Care Excellence. Medicines optimisation: the safe and effective use of medicines to enable the best possible outcomes. NG5. 2015. https://tinyurl.com/yy7ocluh (accessed 10 September 2020)

Nieuwlaat R, Wilczynski N, Navarro T Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2014; 11 https://doi.org/10.1002/14651858.CD000011.pub4

Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005; 353:487-497 https://doi.org/10.1056/NEJMra050100

Parekh N, Ali K, Davies JG Medication-related harm in older adults following hospital discharge: development and validation of a prediction tool. BMJ Qual Saf. 2020; 29:142-153 https://doi.org/10.1136/bmjqs-2019-009587

Patterson SM, Hughes CA, Kerse N, Cardwell CR, Bradley MC. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2012; 5 https://doi.org/10.1002/14651858.CD008165.pub2

Patton DE, Hughes CM, Cadogan CA, Ryan CA. Theory-based interventions to improve medication adherence in older adults prescribed polypharmacy: a systematic review. Drugs Aging. 2017; 34:(2)97-113 https://doi.org/10.1007/s40266-016-0426-6

Pharmacy Magazine. Patients failing to grasp impact of medicines non-adherence. 2017. https://tinyurl.com/y4ft99ht (accessed 10 September 2020)

Royal Pharmaceutical Society. Improving patient outcomes: the better use of multi-compartment compliance aids. 2013. https://tinyurl.com/y436rnnq (accessed 10 September 2020)

Shenoy R, Scott S, Bhattacharya D. Quantifying and characterising multi-compartment compliance aid provision. Pharmacy. 2020; 16:(4)560-567 https://doi.org/10.1016/j.sapharm.2019.07.015

Stavropoulou C. Non-adherence to medication and doctor-patient relationship: evidence from a European survey. Patient Educ Couns. 2011; 83:(1)7-13 https://doi.org/10.1016/j.pec.2010.04.039

Thorell K, Midlöv P, Fastbom J, Halling A. Importance of potentially inappropriate medications, number of chronic conditions and medications for the risk of hospitalisation in elderly in Sweden: a case–control study. BMJ Open. 2019; 9:(9) https://doi.org/10.1136/bmjopen-2019-029477

World Health Organization. Adherence to long term therapies: evidence for action. 2003. https://tinyurl.com/y8ojkxvr (accessed 10 September 2020)

Medication adherence: understanding the issues and finding solutions

02 November 2020
Volume 2 · Issue 11

Abstract

Medication is the most frequent treatment intervention, and its success depends on patients taking their medicines in line with their prescribed regimen to yield the full benefit of the treatment. Adherence is especially difficult to ensure in those with multimorbidity, who take multiple medications to manage their conditions. Non-adherence is costly for the health service, both through wastage and increased ill-health. Non-adherence may be intentional or non-intentional, and many factors affect an individual's compliance with a medication regimen. There are a variety of aids that may be helpful; however, the interaction with a health professional is very important, both for understanding the reason for non-adherence and for promoting adherence.

The COVID-19 pandemic has highlighted the imperative that people should self-manage their long-term conditions as much as possible, both to maximise their own health gain and quality of life, as well as to avoid the unnecessary use of limited healthcare resources at a time when those resources are under increased demand. Many district nursing clients will be taking more than four medicines with different regimens over a long period of time, and, therefore, it is likely that there will be some non-adherence.

A key element of effective self-management of many long-term conditions is adherence to the prescribed regimen, which may include medication at particular times, as well as other self-care activities, such as adequate hydration, a nutritious diet, exercise or physical activities within capabilities and sufficient rest. This article explores the evidence regarding non-adherence and potential strategies to promote adherence, so that district nurses may better understand the factors underlying non-adherence and their clients' perspective as a precursor to supporting their clients' medication needs.

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