A–Z of prescribing for children
This series focuses on aspects of prescribing for neonates, children and young people, from A–Z. Aspects of pharmacokinetics will be considered, alongside legal considerations, consent and medications in schools
It is commonly stated that children are not just small adults; yet, most paediatric medication doses are still calculated from studies in adults (O'Hara, 2016). A knowledge of physiological differences between children and adults is imperative to have a thorough understanding in differences in pharmacokinetics.
Unless administered intravenously, drugs need to cross semipermeable cell membranes before they finally reach the systemic circulation. There are many other ways in which drugs are administered by extravascular routes, such as via the gastrointestinal (GI) tract, topical or transdermal, and through the lungs being the most common routes (van den Anker et al, 2018). Most drugs in children are administered orally. The taste of medications is an important factor (see ‘T’ later in this series), as children will naturally reject bitter or foul-tasting medications. However, once successfully taken, drugs will enter the stomach and gastric pH needs to be considered (Figure 1).
Register now to continue reading
Thank you for visiting Journal of Prescribing Practice and reading some of our peer-reviewed resources for prescribing professionals. To read more, please register today. You’ll enjoy the following great benefits:
Limited access to our clinical or professional articles
New content and clinical newsletter updates each month