McTaggart S, MacColl G, Gronkowski K Impact of regulatory safety notices on valproate prescribing and pregnancy outcome among women of child-bearing potential in Scotland: a population-based cohort study. BMJ Open. 2022; 12:(4)

Robertson D. Adverse drug reactions. Journal of Prescribing Practice. 2023; 5:(2)56-57

Stroup DF, Berlin JA, Morton SC Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA. 2000; 283:(15)2008-2012

Subramanian A, Azcoaga-Lorenzo A, Anand A Polypharmacy during pregnancy and associated risk factors: a retrospective analysis of 577 medication exposures among 1.5 million pregnancies in the UK, 2000-2019. BMC Med. 2023; 21:(1)

Wang XY, Ying XH, Jiang HY. Antidepressant use during pregnancy and the risk for gestational diabetes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2023; 36:(1)

Prescribing during pregnancy

02 March 2023
Volume 5 · Issue 3


Deborah Robertson provides an overview of recently published articles that may be of interest to non-medical prescribers. Should you wish to look at any of the papers in more detail, a full reference is provided

Last month, the research roundup provided you with an overview of articles looking at adverse drug reactions (Robertson, 2023). This month, three articles will be reviewed that look at the complex issues encountered when prescribing during pregnancy will be reviewed. The first article looks at polypharmacy and associated risks, the second examines the use of antidepressants and the risk of gestational diabetes and the third looks at the impact of regulatory safety notices on prescribing valproate in women with childbearing potential.

This article was published in BMC Medicine, used a retrospective cohort study approach to examine data between 2000 and 2019 (Subramanian et al, 2023). The author's main driver to conduct this research was to shed light on the prevalence of the use of multiple medications in pregnancy and to identify risk factors for polypharmacy. They accessed the Pregnancy Register in the Clinical Practice Research Datalink, which contains the anonymised medical records of over 20 million patients in 973 GP practices. In the pregnancy section, data could be gathered on estimated start and end dates of pregnancy as well as estimated dates for each trimester. GP-issued prescriptions were also accessible during that time.

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