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Drug Breakdown / CPD

Drug Breakdown: Mercaptopurine

Day 1: A metabolite of azathioprine, #mercaptopurine was discovered to be an immunosuppressant circa 1950s. The role for #mercaptopurine developed in leukaemias (acute and maintenance therapy) and...

RAMIPRIL

The concept for the first angiotensin converting enzyme inhibitor (ACEI) was derived from snake venom in the 1950s. An orally active version was eventually found, and captopril was licensed in 1981...

DIAZEPAM

In 1957 the first #benzodiazepine (BZD) chlordiazepoxide was discovered by accident (chance modification of tricyclic-like compounds) as having sedative and anti-convulsant properties. It was marketed...

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