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02 November 2024
Volume 6 · Issue 11

Abstract

Some diabetes drugs ‘linked to lower risk of kidney stones and gout’, study finds

Use of sodium glucose cotransporter 2 (SGLT-2) inhibitor drugs to treat type 2 diabetes may also help to lower the risk of recurrent kidney stones and gout flare-ups, finds a study from Canada published by The BMJ.

Kidney stones (nephrolithiasis) and gout are both common, recurrent, extremely painful conditions, especially in patients with type 2 diabetes. They also incur substantial healthcare costs.

As well as treating type 2 diabetes, trials have shown that SGLT-2 inhibitors can also lower the risk of heart failure and kidney disease, but their effect on recurrent kidney stones and gout flare-ups is still uncertain.

To explore this further, researchers set out to compare the effects of SGLT-2 inhibitors on risk of recurrent kidney stones and gout with two other groups of diabetes drugs known as GLP-1 receptor agonists and DPP-4 inhibitors.

Their findings are based on data for 20 146 adults (average age 65; 73% men) with type 2 diabetes and a history of kidney stones, gout, or both, who had not previously used SGLT-2 inhibitors, GLP-1 receptor agonists or DPP-4 inhibitors.

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