World Health Organization fungal priority pathogens list: answers

Adult, weighing 65 kg with aspergillosis is prescribed IV amphotericin B by intravenous infusion. The BNF recommends 3 mg/kg once daily with a maximum dose of 5 mg/kg per day. What minimum and maximum daily dose could be prescribed?

Adult, weight 43 kg with systemic fungal infection is prescribed IV amphotericin B by intravenous infusion. The BNF recommends day 1 dose of 250 micrograms/kg daily to be increased as tolerated to 1.5 mg/kg on alternate days. What is the dose to be prescribed for day 1? What is the maximum alternate day dose?

A 5-year-old child, weighing 24 kg with oropharyngeal candidiasis is prescribed IV fluconazole. The BNF (2024a) recommends 3 mg/kg up to maximum 6mg/kg dose to be given on the first day. What is the minimum and maximum dose that can be prescribed on the first day? What is the daily dosage up to day 7 to 14?